Transient and selective overexpression of D(2) receptors in the striatum causes persistent deficits in conditional associative learning

Cognitive deficits in schizophrenia are thought to derive from a hypofunction of the prefrontal cortex (PFC), but the origin of the hypofunction is unclear. To explore the nature of this deficit, we genetically modified mice to model the increase in striatal dopamine D(2) receptors (D(2)Rs) observed...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Bach, Mary-Elizabeth, Simpson, Eleanor H., Kahn, Lora, Marshall, John J., Kandel, Eric R., Kellendonk, Christoph
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572912/
https://ncbi.nlm.nih.gov/pubmed/18832466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807746105
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