Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia

We previously showed that mice that selectively and reversibly overexpress striatal D2 receptors (D2R-OE) model the negative symptoms of schizophrenia. Specifically, D2R-OE mice display a deficit in incentive motivation. The present studies investigated the basis for this deficit. First, we assessed...

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Autors principals: Ward, Ryan D, Simpson, Eleanor H, Richards, Vanessa L, Deo, Gita, Taylor, Kathleen, Glendinning, John I, Kandel, Eric R, Balsam, Peter D
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358738/
https://ncbi.nlm.nih.gov/pubmed/22414818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.15
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