Dissociation of Hedonic Reaction to Reward and Incentive Motivation in an Animal Model of the Negative Symptoms of Schizophrenia

We previously showed that mice that selectively and reversibly overexpress striatal D2 receptors (D2R-OE) model the negative symptoms of schizophrenia. Specifically, D2R-OE mice display a deficit in incentive motivation. The present studies investigated the basis for this deficit. First, we assessed...

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Main Authors: Ward, Ryan D, Simpson, Eleanor H, Richards, Vanessa L, Deo, Gita, Taylor, Kathleen, Glendinning, John I, Kandel, Eric R, Balsam, Peter D
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358738/
https://ncbi.nlm.nih.gov/pubmed/22414818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.15
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