Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

Por Marcotte, Douglas J., Liu, YuTing, Little, Kevin, Jones, John H., Powell, Noel A., Wildes, Craig P., Silvian, Laura F., Chodaparambil, Jayanth V.
Publicado no BMC Struct Biol (2016)

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Por Ma, Bin, Marcotte, Doug, Paramasivam, Murugan, Michelsen, Klaus, Wang, Ti, Bertolotti-Ciarlet, Andrea, Jones, John Howard, Moree, Ben, Butko, Margaret, Salafsky, Joshua, Sun, Xin, McKee, Timothy, Silvian, Laura F.
Publicado no PLoS One (2016)

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand Through a Subunit Fracture Mechanism

Por Silvian, Laura F., Friedman, Jessica E., Strauch, Kathy, Cachero, Teresa G., Day, Eric S., Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Shipps, Gerald W., Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian
Publicado em 2011

Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure

Por Marcotte, Douglas J., Hus, Jean‐Christophe, Banos, Charles C., Wildes, Craig, Arduini, Robert, Bergeron, Chris, Hession, Catherine A., Baker, Darren P., Lin, Edward, Guckian, Kevin M., Dunah, Anthone W., Silvian, Laura F.
Publicado no Protein Sci (2018)

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Por Marcotte, Douglas J, Liu, Yu-Ting, Arduini, Robert M, Hession, Catherine A, Miatkowski, Konrad, Wildes, Craig P, Cullen, Patrick F, Hong, Victor, Hopkins, Brian T, Mertsching, Elisabeth, Jenkins, Tracy J, Romanowski, Michael J, Baker, Darren P, Silvian, Laura F
Publicado em 2010

Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

Por Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May‐Dracka, Tricia L., Xin, Zhili, Bertolotti‐Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.
Publicado no Protein Sci (2016)

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Por Lin, Edward Y. S., Silvian, Laura F., Marcotte, Douglas J., Banos, Charles C., Jow, Flora, Chan, Timothy R., Arduini, Robert M., Qian, Fang, Baker, Darren P., Bergeron, Chris, Hession, Catherine A., Huganir, Richard L., Borenstein, Cassandra F., Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J., Scannevin, Robert H., Dunah, Anthone W., Guckian, Kevin M.
Publicado no Sci Rep (2018)