Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Bruton's tyrosine kinase (BTK), a member of the TEC family of kinases, plays a crucial role in B-cell maturation and mast cell activation. Although the structures of the unphosphorylated mouse BTK kinase domain and the unphosphorylated and phosphorylated kinase domains of human ITK are known, u...

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Detalhes bibliográficos
Main Authors: Marcotte, Douglas J, Liu, Yu-Ting, Arduini, Robert M, Hession, Catherine A, Miatkowski, Konrad, Wildes, Craig P, Cullen, Patrick F, Hong, Victor, Hopkins, Brian T, Mertsching, Elisabeth, Jenkins, Tracy J, Romanowski, Michael J, Baker, Darren P, Silvian, Laura F
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2866269/
https://ncbi.nlm.nih.gov/pubmed/20052711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.321
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