Design of Potent and Selective Covalent Inhibitors of Bruton’s Tyrosine Kinase Targeting an Inactive Conformation

[Image: see text] Bruton’s tyrosine kinase (BTK) is a member of the TEC kinase family and is selectively expressed in a subset of immune cells. It is a key regulator of antigen receptor signaling in B cells and of Fc receptor signaling in mast cells and macrophages. A BTK inhibitor will likely have...

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Publicado no:ACS Med Chem Lett
Main Authors: Pulz, Robert, Angst, Daniela, Dawson, Janet, Gessier, Francois, Gutmann, Sascha, Hersperger, Rene, Hinniger, Alexandra, Janser, Philipp, Koch, Guido, Revesz, Laszlo, Vulpetti, Anna, Waelchli, Rudolf, Zimmerlin, Alfred, Cenni, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792172/
https://ncbi.nlm.nih.gov/pubmed/31620235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00317
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