Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity

[Image: see text] Bruton’s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in the pathology of autoimmune disorders, BTK inhibitors have the potential to improve treat...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Bacani, Genesis M., Wei, Jianmei, Chang, Leon, Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, JieJun, Seierstad, Mark, Bembenek, Scott D., Leonard, Kristi A., Lebsack, Alec D., Venable, Jennifer D., Edwards, James P.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2021
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155241/
https://ncbi.nlm.nih.gov/pubmed/34055226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00044
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