Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity

[Image: see text] Bruton’s tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase that plays a critical role in the activation of B cells, macrophages, and osteoclasts. Given the key role of these cell types in the pathology of autoimmune disorders, BTK inhibitors have the potential to improve treat...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Tichenor, Mark S., Wiener, John J. M., Rao, Navin L., Pooley Deckhut, Charlotte, Barbay, J. Kent, Kreutter, Kevin D., Bacani, Genesis M., Wei, Jianmei, Chang, Leon, Murrey, Heather E., Wang, Weixue, Ahn, Kay, Huber, Michael, Rex, Elizabeth, Coe, Kevin J., Wu, JieJun, Seierstad, Mark, Bembenek, Scott D., Leonard, Kristi A., Lebsack, Alec D., Venable, Jennifer D., Edwards, James P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155241/
https://ncbi.nlm.nih.gov/pubmed/34055226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00044
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