Inhibition of Bruton tyrosine kinase in patients with severe COVID-19

Patients with severe COVID-19 have a hyperinflammatory immune response suggestive of macrophage activation. Bruton tyrosine kinase (BTK) regulates macrophage signaling and activation. Acalabrutinib, a selective BTK inhibitor, was administered off-label to 19 patients hospitalized with severe COVID-1...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Roschewski, Mark, Lionakis, Michail S., Sharman, Jeff P., Roswarski, Joseph, Goy, Andre, Monticelli, M. Andrew, Roshon, Michael, Wrzesinski, Stephen H., Desai, Jigar V., Zarakas, Marissa A., Collen, Jacob, Rose, Keith, Hamdy, Ahmed, Izumi, Raquel, Wright, George W., Chung, Kevin K., Baselga, Jose, Staudt, Louis M., Wilson, Wyndham H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274761/
https://ncbi.nlm.nih.gov/pubmed/32503877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.abd0110
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