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Ibrutinib: a first in class covalent inhibitor of Bruton’s tyrosine kinase

Ibrutinib (formerly PCI-32765) is a potent, covalent inhibitor of Bruton’s tyrosine kinase, a kinase downstream of the B-cell receptor that is critical for B-cell survival and proliferation. In preclinical studies, ibrutinib bound to Bruton’s tyrosine kinase with high affinity, leading to inhibition...

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Detalhes bibliográficos
Publicado no:Future Oncol
Main Authors: Davids, Matthew S, Brown, Jennifer R
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632638/
https://ncbi.nlm.nih.gov/pubmed/24941982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fon.14.51
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