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Absence of Tec Family Kinases Interleukin-2 Inducible T cell Kinase (Itk) and Bruton's Tyrosine Kinase (Btk) Severely Impairs FcϵRI-dependent Mast Cell Responses

Mast cells are critical effector cells in the pathophysiology of allergic asthma and other IgE-mediated diseases. The Tec family of tyrosine kinases Itk and Btk serve as critical signal amplifiers downstream of antigen receptors. Although both kinases are expressed and activated in mast cells follow...

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Detaylı Bibliyografya
Asıl Yazarlar: Iyer, Archana S., Morales, J. Luis, Huang, Weishan, Ojo, Folake, Ning, Gang, Wills, Elizabeth, Baines, Joel D., August, Avery
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059023/
https://ncbi.nlm.nih.gov/pubmed/21212279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165613
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