Synthesis and screening of small molecule libraries active in binding to DNA

Autor Shipps, Gerald W., Pryor, Kent E., Xian, Jun, Skyler, David A., Davidson, Eric H., Rebek, Julius
Vydáno 1997

Discovery of a Novel Series of CHK1 Kinase Inhibitors with a Distinctive Hinge Binding Mode

Autor Huang, Xiaohua, Cheng, Cliff C., Fischmann, Thierry O., Duca, José S., Yang, Xianshu, Richards, Matthew, Shipps, Gerald W.
Vydáno 2012

Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

Autor Ma, Yao, Lahue, Brian R., Gibeau, Craig R., Shipps, Gerald W., Bogen, Stéphane L., Wang, Yaolin, Guo, Zhuyan, Guzi, Timothy J.
Vydáno 2014

Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase

Autor Cheng, Cliff C., Huang, Xiaohua, Shipps, Gerald W., Wang, Yu-Sen, Wyss, Daniel F., Soucy, Kyle A., Jiang, Chuan-kui, Agrawal, Sony, Ferrari, Eric, He, Zhiqing, Huang, H.-C.
Vydáno 2010

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand Through a Subunit Fracture Mechanism

Autor Silvian, Laura F., Friedman, Jessica E., Strauch, Kathy, Cachero, Teresa G., Day, Eric S., Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Shipps, Gerald W., Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian
Vydáno 2011

Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors

Autor Huang, Xiaohua, Shipps, Gerald W., Cheng, Cliff C., Spacciapoli, Peter, Zhang, Xingmin, McCoy, Mark A., Wyss, Daniel F., Yang, Xianshu, Achab, Abdelghani, Soucy, Kyle, Montavon, Donna K., Murphy, Denise M., Whitehurst, Charles E.
Vydáno 2011

Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity

Autor Lan, Hong, Cheng, Cliff C., Kowalski, Timothy J., Pang, Ling, Shan, Lixin, Chuang, Cheng-Chi, Jackson, James, Rojas-Triana, Alberto, Bober, Loretta, Liu, Li, Voigt, Johannes, Orth, Peter, Yang, Xianshu, Shipps, Gerald W., Hedrick, Joseph A.
Vydáno 2011

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

Autor Bogen, Stéphane L., Pan, Weidong, Gibeau, Craig R., Lahue, Brian R., Ma, Yao, Nair, Latha G., Seigel, Elise, Shipps, Gerald W., Tian, Yuan, Wang, Yaolin, Lin, Yinghui, Liu, Ming, Liu, Suxing, Mirza, Asra, Wang, Xiaoying, Lipari, Philip, Seidel-Dugan, Cynthia, Hicklin, Daniel J., Bishop, W. Robert, Rindgen, Diane, Nomeir, Amin, Prosise, Winifred, Reichert, Paul, Scapin, Giovanna, Strickland, Corey, Doll, Ronald J.
Vydáno v ACS Med Chem Lett (2016)

Development of MK-8353, an orally administered ERK1/2 inhibitor, in patients with advanced solid tumors

Autor Moschos, Stergios J., Sullivan, Ryan J., Hwu, Wen-Jen, Ramanathan, Ramesh K., Adjei, Alex A., Fong, Peter C., Shapira-Frommer, Ronnie, Tawbi, Hussein A., Rubino, Joseph, Rush, Thomas S., Zhang, Da, Miselis, Nathan R., Samatar, Ahmed A., Chun, Patrick, Rubin, Eric H., Schiller, James, Long, Brian J., Dayananth, Priya, Carr, Donna, Kirschmeier, Paul, Bishop, W. Robert, Deng, Yongqi, Cooper, Alan, Shipps, Gerald W., Moreno, Blanca Homet, Robert, Lidia, Ribas, Antoni, Flaherty, Keith T.
Vydáno v JCI Insight (2018)

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology

Autor Boga, Sobhana Babu, Deng, Yongqi, Zhu, Liang, Nan, Yang, Cooper, Alan B., Shipps, Gerald W., Doll, Ronald, Shih, Neng-Yang, Zhu, Hugh, Sun, Robert, Wang, Tong, Paliwal, Sunil, Tsui, Hon-Chung, Gao, Xiaolei, Yao, Xin, Desai, Jagdish, Wang, James, Alhassan, Abdul Basit, Kelly, Joseph, Patel, Mehul, Muppalla, Kiran, Gudipati, Subrahmanyam, Zhang, Li-Kang, Buevich, Alexei, Hesk, David, Carr, Donna, Dayananth, Priya, Black, Stuart, Mei, Hong, Cox, Kathleen, Sherborne, Bradley, Hruza, Alan W., Xiao, Li, Jin, Weihong, Long, Brian, Liu, Gongjie, Taylor, Stacey A., Kirschmeier, Paul, Windsor, William T., Bishop, Robert, Samatar, Ahmed A.
Vydáno v ACS Med Chem Lett (2018)