Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase

[Image: see text] Pyridine carboxamide-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified and optimized to a variety of topologically related scaffolds. In particular, the 2-methyl nicotinic acid scaffold was developed into inhibitors with improved biochemical (IC(50)-G...

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Xehetasun bibliografikoak
Egile Nagusiak: Cheng, Cliff C., Huang, Xiaohua, Shipps, Gerald W., Wang, Yu-Sen, Wyss, Daniel F., Soucy, Kyle A., Jiang, Chuan-kui, Agrawal, Sony, Ferrari, Eric, He, Zhiqing, Huang, H.-C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2010
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007899/
https://ncbi.nlm.nih.gov/pubmed/24900232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100128h
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