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Pyridine Carboxamides: Potent Palm Site Inhibitors of HCV NS5B Polymerase
[Image: see text] Pyridine carboxamide-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified and optimized to a variety of topologically related scaffolds. In particular, the 2-methyl nicotinic acid scaffold was developed into inhibitors with improved biochemical (IC(50)-G...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical Society
2010
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4007899/ https://ncbi.nlm.nih.gov/pubmed/24900232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100128h |
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