Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

Por Ma, Yao, Lahue, Brian R., Gibeau, Craig R., Shipps, Gerald W., Bogen, Stéphane L., Wang, Yaolin, Guo, Zhuyan, Guzi, Timothy J.
Publicado em 2014

Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors

Por Bogen, Stéphane L., Pan, Weidong, Gibeau, Craig R., Lahue, Brian R., Ma, Yao, Nair, Latha G., Seigel, Elise, Shipps, Gerald W., Tian, Yuan, Wang, Yaolin, Lin, Yinghui, Liu, Ming, Liu, Suxing, Mirza, Asra, Wang, Xiaoying, Lipari, Philip, Seidel-Dugan, Cynthia, Hicklin, Daniel J., Bishop, W. Robert, Rindgen, Diane, Nomeir, Amin, Prosise, Winifred, Reichert, Paul, Scapin, Giovanna, Strickland, Corey, Doll, Ronald J.
Publicado no ACS Med Chem Lett (2016)

Key steps in the structure-based optimization of the hepatitis C virus NS3/4A protease inhibitor SCH503034

Por Madison, Vincent, Prongay, Andrew J., Guo, Zhuyan, Yao, Nanhua, Pichardo, John, Fischmann, Thierry, Strickland, Corey, Myers Jr, Joseph, Weber, Patricia C., Beyer, Brian M., Ingram, Richard, Hong, Zhi, Prosise, Winifred W., Ramanathan, Lata, Taremi, S. Shane, Yarosh-Tomaine, Taisa, Zhang, Rumin, Senior, Mary, Yang, Rong-Sheng, Malcolm, Bruce, Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Chen, Kevin, Jao, Edwin, Liu, Yi-Tsung, Lovey, Raymond G., Saksena, Anil K., Venkatraman, Srikanth, Girijavallabhan, Viyyoor, Njoroge, F. George
Publicado em 2008

Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor

Por Arasappan, Ashok, Bennett, Frank, Bogen, Stephane L., Venkatraman, Srikanth, Blackman, Melissa, Chen, Kevin X., Hendrata, Siska, Huang, Yuhua, Huelgas, Regina M., Nair, Latha, Padilla, Angela I., Pan, Weidong, Pike, Russell, Pinto, Patrick, Ruan, Sumei, Sannigrahi, Mousumi, Velazquez, Francisco, Vibulbhan, Bancha, Wu, Wanli, Yang, Weiying, Saksena, Anil K., Girijavallabhan, Viyyoor, Shih, Neng-Yang, Kong, Jianshe, Meng, Tao, Jin, Yan, Wong, Jesse, McNamara, Paul, Prongay, Andrew, Madison, Vincent, Piwinski, John J., Cheng, Kuo-Chi, Morrison, Richard, Malcolm, Bruce, Tong, Xiao, Ralston, Robert, Njoroge, F. George
Publicado em 2010