Pivotal Role of an Aliphatic Side Chain in the Development of an HDM2 Inhibitor

[Image: see text] Introduction of an aliphatic side chain to a key position of a novel piperidine-based HDM2 inhibitor scaffold resulted in significant potency gains, enabling further series progression.

Guardado en:
Detalles Bibliográficos
Autores principales: Ma, Yao, Lahue, Brian R., Gibeau, Craig R., Shipps, Gerald W., Bogen, Stéphane L., Wang, Yaolin, Guo, Zhuyan, Guzi, Timothy J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027732/
https://ncbi.nlm.nih.gov/pubmed/24900882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500019s
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares