Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors

[Image: see text] A novel series of non-ATP-competitive MK2 inhibitors based on a furan-2-carboxyamide scaffold was discovered through high-throughput screening using the affinity selection–mass spectrometry-based Automated Ligand Identification System platform. Medicinal chemistry efforts optimized...

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Detalhes bibliográficos
Main Authors: Huang, Xiaohua, Shipps, Gerald W., Cheng, Cliff C., Spacciapoli, Peter, Zhang, Xingmin, McCoy, Mark A., Wyss, Daniel F., Yang, Xianshu, Achab, Abdelghani, Soucy, Kyle, Montavon, Donna K., Murphy, Denise M., Whitehurst, Charles E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017987/
https://ncbi.nlm.nih.gov/pubmed/24900358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200113y
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