The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are incompletely understood. Here we show that two related s...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Wei, Yongjie, An, Zhenyi, Zou, Zhongju, Sumpter, Rhea, Su, Minfei, Zang, Xiao, Sinha, Sangita, Gaestel, Matthias, Levine, Beth
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2015
Предметы:
Biochemistry
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337728/
https://ncbi.nlm.nih.gov/pubmed/25693418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05289
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