The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are incompletely understood. Here we show that two related s...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Wei, Yongjie, An, Zhenyi, Zou, Zhongju, Sumpter, Rhea, Su, Minfei, Zang, Xiao, Sinha, Sangita, Gaestel, Matthias, Levine, Beth
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2015
Teme:
Biochemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337728/
https://ncbi.nlm.nih.gov/pubmed/25693418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05289
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