Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

Germinal‐center kinase‐like kinase (GLK, Map4k3), a GCK‐I family kinase, plays multiple roles in regulating apoptosis, amino acid sensing, and immune signaling. We describe here the crystal structure of an activation loop mutant of GLK kinase domain bound to an inhibitor. The structure reveals a wea...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May‐Dracka, Tricia L., Xin, Zhili, Bertolotti‐Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5275742/
https://ncbi.nlm.nih.gov/pubmed/27727493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3062
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados