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The domain-swapping switch point in Ste20 protein kinase SPAK

The related protein kinases SPAK and OSR1 regulate ion homeostasis in part by phosphorylating cation cotransporter family members. The structure of the kinase domain of OSR1 was solved in the unphosphorylated inactive form, and like some other Ste20 kinases, exhibited a domain-swapped activation loo...

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Publicat a:Biochemistry
Autors principals: Taylor, Clinton A., Juang, Yu-Chi, Earnest, Svetlana, Sengupta, Samarpita, Goldsmith, Elizabeth J., Cobb, Melanie H.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5167558/
https://ncbi.nlm.nih.gov/pubmed/26208601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00593
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