The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor

per Marcotte, Douglas J., Spilker, Kerri A., Wen, Dingyi, Hesson, Thomas, Patterson, Thomas A., Kumar, P. Rajesh, Chodaparambil, Jayanth V.
Publicat a Acta Crystallogr F Struct Biol Commun (2020)

Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

per Marcotte, Douglas J., Liu, YuTing, Little, Kevin, Jones, John H., Powell, Noel A., Wildes, Craig P., Silvian, Laura F., Chodaparambil, Jayanth V.
Publicat a BMC Struct Biol (2016)

Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors

per Xin, Zhili, Himmelbauer, Martin K., Jones, J. Howard, Enyedy, Istvan, Gilfillan, Rab, Hesson, Thomas, King, Kristopher, Marcotte, Douglas J., Murugan, Paramasivam, Santoro, Joseph C., Gonzalez-Lopez de Turiso, Felix
Publicat a ACS Med Chem Lett (2020)

Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure

per Marcotte, Douglas J., Hus, Jean‐Christophe, Banos, Charles C., Wildes, Craig, Arduini, Robert, Bergeron, Chris, Hession, Catherine A., Baker, Darren P., Lin, Edward, Guckian, Kevin M., Dunah, Anthone W., Silvian, Laura F.
Publicat a Protein Sci (2018)

Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor BIO-32546

per Ma, Bin, Zhang, Lei, Sun, Lihong, Xin, Zhili, Kumaravel, Gnanasambandam, Marcotte, Douglas, Chodaparambil, Jayanth V., Wang, Qin, Wehr, Angela, Jing, Jing, Hong, Victor Sukbong, Wang, Ti, Huang, Carol, Shao, Zhaohui, Mi, Sha
Publicat a ACS Med Chem Lett (2021)

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

per Marcotte, Douglas J, Liu, Yu-Ting, Arduini, Robert M, Hession, Catherine A, Miatkowski, Konrad, Wildes, Craig P, Cullen, Patrick F, Hong, Victor, Hopkins, Brian T, Mertsching, Elisabeth, Jenkins, Tracy J, Romanowski, Michael J, Baker, Darren P, Silvian, Laura F
Publicat 2010

Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study

per Argiriadi, Maria A, Sousa, Silvino, Banach, David, Marcotte, Douglas, Xiang, Tao, Tomlinson, Medha J, Demers, Megan, Harris, Christopher, Kwak, Silvia, Hardman, Jennifer, Pietras, Margaret, Quinn, Lisa, DiMauro, Jennifer, Ni, Baofu, Mankovich, John, Borhani, David W, Talanian, Robert V, Sadhukhan, Ramkrishna
Publicat 2009

Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol

per Goedken, Eric R., Argiriadi, Maria A., Banach, David L., Fiamengo, Bryan A., Foley, Sage E., Frank, Kristine E., George, Jonathan S., Harris, Christopher M., Hobson, Adrian D., Ihle, David C., Marcotte, Douglas, Merta, Philip J., Michalak, Mark E., Murdock, Sara E., Tomlinson, Medha J., Voss, Jeffrey W.
Publicat a J Biol Chem (2015)

Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

per Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May‐Dracka, Tricia L., Xin, Zhili, Bertolotti‐Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.
Publicat a Protein Sci (2016)

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

per Lin, Edward Y. S., Silvian, Laura F., Marcotte, Douglas J., Banos, Charles C., Jow, Flora, Chan, Timothy R., Arduini, Robert M., Qian, Fang, Baker, Darren P., Bergeron, Chris, Hession, Catherine A., Huganir, Richard L., Borenstein, Cassandra F., Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J., Scannevin, Robert H., Dunah, Anthone W., Guckian, Kevin M.
Publicat a Sci Rep (2018)