Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand

Autor Marcotte, Douglas J., Liu, YuTing, Little, Kevin, Jones, John H., Powell, Noel A., Wildes, Craig P., Silvian, Laura F., Chodaparambil, Jayanth V.
Vydáno v BMC Struct Biol (2016)

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

Autor Pepinsky, R Blake, Silvian, Laura, Berkowitz, Steven A, Farrington, Graham, Lugovskoy, Alexey, Walus, Lee, Eldredge, John, Capili, Allan, Mi, Sha, Graff, Christilyn, Garber, Ellen
Vydáno 2010

ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis

Autor Ma, Bin, Marcotte, Doug, Paramasivam, Murugan, Michelsen, Klaus, Wang, Ti, Bertolotti-Ciarlet, Andrea, Jones, John Howard, Moree, Ben, Butko, Margaret, Salafsky, Joshua, Sun, Xin, McKee, Timothy, Silvian, Laura F.
Vydáno v PLoS One (2016)

Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand Through a Subunit Fracture Mechanism

Autor Silvian, Laura F., Friedman, Jessica E., Strauch, Kathy, Cachero, Teresa G., Day, Eric S., Qian, Fang, Cunningham, Brian, Fung, Amy, Sun, Lihong, Shipps, Gerald W., Su, Lihe, Zheng, Zhongli, Kumaravel, Gnanasambandam, Whitty, Adrian
Vydáno 2011

Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine‐based inhibitor co‐crystal structure

Autor Marcotte, Douglas J., Hus, Jean‐Christophe, Banos, Charles C., Wildes, Craig, Arduini, Robert, Bergeron, Chris, Hession, Catherine A., Baker, Darren P., Lin, Edward, Guckian, Kevin M., Dunah, Anthone W., Silvian, Laura F.
Vydáno v Protein Sci (2018)

Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases

Autor Marcotte, Douglas J, Liu, Yu-Ting, Arduini, Robert M, Hession, Catherine A, Miatkowski, Konrad, Wildes, Craig P, Cullen, Patrick F, Hong, Victor, Hopkins, Brian T, Mertsching, Elisabeth, Jenkins, Tracy J, Romanowski, Michael J, Baker, Darren P, Silvian, Laura F
Vydáno 2010

Germinal‐center kinase‐like kinase co‐crystal structure reveals a swapped activation loop and C‐terminal extension

Autor Marcotte, Douglas, Rushe, Mia, M. Arduini, Robert, Lukacs, Christine, Atkins, Kateri, Sun, Xin, Little, Kevin, Cullivan, Michael, Paramasivam, Murugan, Patterson, Thomas A., Hesson, Thomas, D. McKee, Timothy, May‐Dracka, Tricia L., Xin, Zhili, Bertolotti‐Ciarlet, Andrea, Bhisetti, Govinda R., Lyssikatos, Joseph P., Silvian, Laura F.
Vydáno v Protein Sci (2016)

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Autor Lin, Edward Y. S., Silvian, Laura F., Marcotte, Douglas J., Banos, Charles C., Jow, Flora, Chan, Timothy R., Arduini, Robert M., Qian, Fang, Baker, Darren P., Bergeron, Chris, Hession, Catherine A., Huganir, Richard L., Borenstein, Cassandra F., Enyedy, Istvan, Zou, Jinming, Rohde, Ellen, Wittmann, Marion, Kumaravel, Gnanasambandam, Rhodes, Kenneth J., Scannevin, Robert H., Dunah, Anthone W., Guckian, Kevin M.
Vydáno v Sci Rep (2018)