Imaging of cerebrovascular pathology in animal models of Alzheimer's disease

Por Klohs, Jan, Rudin, Markus, Shimshek, Derya R., Beckmann, Nicolau
Publicado em 2014

Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging

Por Longo, Francesco, Russo, Isabella, Shimshek, Derya R., Greggio, Elisa, Morari, Michele
Publicado em 2014

Excess α-synuclein worsens disease in mice lacking ubiquitin carboxy-terminal hydrolase L1

Por Shimshek, Derya R., Schweizer, Tatjana, Schmid, Peter, van der Putten, P. Herman
Publicado em 2012

The HSP70 Molecular Chaperone Is Not Beneficial in a Mouse Model of α-synucleinopathy

Por Shimshek, Derya R., Mueller, Matthias, Wiessner, Christoph, Schweizer, Tatjana, van der Putten, P. Herman
Publicado em 2010

Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis

Por Miklavc, Pika, Ehinger, Konstantin, Thompson, Kristin E., Hobi, Nina, Shimshek, Derya R., Frick, Manfred
Publicado em 2014

Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na(+)/K(+) ATPase Activity in Dendritic Cells

Por Hosseinzadeh, Zohreh, Singh, Yogesh, Shimshek, Derya R., van der Putten, Herman, Wagner, Carsten A., Lang, Florian
Publicado no Sci Rep (2017)

Enhanced Odor Discrimination and Impaired Olfactory Memory by Spatially Controlled Switch of AMPA Receptors

Por Shimshek, Derya R, Bus, Thorsten, Kim, Jinhyun, Mihaljevic, Andre, Mack, Volker, Seeburg, Peter H, Sprengel, Rolf, Schaefer, Andreas T
Publicado em 2005

Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation

Por Shimshek, Derya R., Bus, Thorsten, Schupp, Bettina, Jensen, Vidar, Marx, Verena, Layer, Liliana E., Köhr, Georg, Sprengel, Rolf
Publicado no Front Mol Neurosci (2017)

Novel One-step Immunoassays to Quantify α-Synuclein: APPLICATIONS FOR BIOMARKER DEVELOPMENT AND HIGH-THROUGHPUT SCREENING

Por Bidinosti, Michael, Shimshek, Derya R., Mollenhauer, Brit, Marcellin, David, Schweizer, Tatjana, Lotz, Gregor P., Schlossmacher, Michael G., Weiss, Andreas
Publicado em 2012

Mutant Huntingtin Gene-Dose Impacts on Aggregate Deposition, DARPP32 Expression and Neuroinflammation in HdhQ150 Mice

Por Young, Douglas, Mayer, Franziska, Vidotto, Nella, Schweizer, Tatjana, Berth, Ramon, Abramowski, Dorothee, Shimshek, Derya R., van der Putten, P. Herman, Schmid, Peter
Publicado em 2013

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

Por Longo, Francesco, Mercatelli, Daniela, Novello, Salvatore, Arcuri, Ludovico, Brugnoli, Alberto, Vincenzi, Fabrizio, Russo, Isabella, Berti, Giulia, Mabrouk, Omar S., Kennedy, Robert T., Shimshek, Derya R., Varani, Katia, Bubacco, Luigi, Greggio, Elisa, Morari, Michele
Publicado no Acta Neuropathol Commun (2017)

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

Por Keskin, Aylin D., Kekuš, Maja, Adelsberger, Helmuth, Neumann, Ulf, Shimshek, Derya R., Song, Beomjong, Zott, Benedikt, Peng, Tingying, Förstl, Hans, Staufenbiel, Matthias, Nelken, Israel, Sakmann, Bert, Konnerth, Arthur, Busche, Marc Aurel
Publicado no Proc Natl Acad Sci U S A (2017)

Neuropathology in Mice Expressing Mouse Alpha-Synuclein

Por Rieker, Claus, Dev, Kumlesh K., Lehnhoff, Katja, Barbieri, Samuel, Ksiazek, Iwona, Kauffmann, Sabine, Danner, Simone, Schell, Heinrich, Boden, Cindy, Ruegg, Markus A., Kahle, Philipp J., van der Putten, Herman, Shimshek, Derya R.
Publicado em 2011

A novel BACE inhibitor NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice

Por Neumann, Ulf, Rueeger, Heinrich, Machauer, Rainer, Veenstra, Siem Jacob, Lueoend, Rainer M., Tintelnot-Blomley, Marina, Laue, Grit, Beltz, Karen, Vogg, Barbara, Schmid, Peter, Frieauff, Wilfried, Shimshek, Derya R., Staufenbiel, Matthias, Jacobson, Laura H.
Publicado no Mol Neurodegener (2015)

High LRRK2 Levels Fail to Induce or Exacerbate Neuronal Alpha-Synucleinopathy in Mouse Brain

Por Herzig, Martin C., Bidinosti, Michael, Schweizer, Tatjana, Hafner, Thomas, Stemmelen, Christine, Weiss, Andreas, Danner, Simone, Vidotto, Nella, Stauffer, Daniela, Barske, Carmen, Mayer, Franziska, Schmid, Peter, Rovelli, Giorgio, van der Putten, P. Herman, Shimshek, Derya R.
Publicado em 2012

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice

Por Shimshek, Derya R., Jacobson, Laura H., Kolly, Carine, Zamurovic, Natasa, Balavenkatraman, Kamal Kumar, Morawiec, Laurent, Kreutzer, Robert, Schelle, Juliane, Jucker, Mathias, Bertschi, Barbara, Theil, Diethilde, Heier, Annabelle, Bigot, Karine, Beltz, Karen, Machauer, Rainer, Brzak, Irena, Perrot, Ludovic, Neumann, Ulf
Publicado no Sci Rep (2016)

Fragments of HdhQ150 Mutant Huntingtin Form a Soluble Oligomer Pool That Declines with Aggregate Deposition upon Aging

Por Marcellin, David, Abramowski, Dorothee, Young, Douglas, Richter, Jens, Weiss, Andreas, Marcel, Audrey, Maassen, Julia, Kauffmann, Muriel, Bibel, Miriam, Shimshek, Derya R., Faull, Richard L. M., Bates, Gillian P., Kuhn, Rainer R., Van der Putten, P. Herman, Schmid, Peter, Lotz, Gregor P.
Publicado em 2012

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

Por Herzig, Martin C., Kolly, Carine, Persohn, Elke, Theil, Diethilde, Schweizer, Tatjana, Hafner, Thomas, Stemmelen, Christine, Troxler, Thomas J., Schmid, Peter, Danner, Simone, Schnell, Christian R., Mueller, Matthias, Kinzel, Bernd, Grevot, Armelle, Bolognani, Federico, Stirn, Martina, Kuhn, Rainer R., Kaupmann, Klemens, van der Putten, P. Herman, Rovelli, Giorgio, Shimshek, Derya R.
Publicado em 2011