Inhibition of hydrogen peroxide signaling by 4-Hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatoc...

af Shearn, Colin T., Reigan, Philip, Petersen, Dennis R.
Udgivet 2012

Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease

af Shearn, Colin T., Orlicky, David J., Petersen, Dennis R.
Udgivet i Exp Mol Pathol (2017)

Lipid peroxidation derived reactive aldehydes in alcoholic liver disease

af Ali, Hadi, Assiri, Mohammed A., Shearn, Colin T., Fritz, Kristofer S.
Udgivet i Curr Opin Toxicol (2018)

Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis

af Hail, Numsen, Chen, Ping, Kepa, Jadwiga J., Bushman, Lane R., Shearn, Colin
Udgivet 2010

Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model

af Senchina, David S., Flinn, Gina N., McCann, Dustin A., Kohut, Marian L., Shearn, Colin T.
Udgivet 2009

Identification of 5′ AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol

af Shearn, Colin T., Backos, Donald S., Orlicky, David J., Smathers-McCullough, Rebecca L., Petersen, Dennis R.
Udgivet 2014

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early stage ethanol-mediated steatosis

af Shearn, Colin T., Smathers, Rebecca L., Jiang, Hua, Orlicky, David J., Maclean, Kenneth N., Petersen, Dennis R.
Udgivet 2013

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Signaling Regulates Mitochondrial Biogenesis and Respiration via Estrogen-related Receptor α (ERRα)

af Li, Yang, He, Lina, Zeng, Ni, Sahu, Divya, Cadenas, Enrique, Shearn, Colin, Li, Wei, Stiles, Bangyan L.
Udgivet 2013

Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH

af Shearn, Colin T., Saba, Laura M., Roede, James R., Orlicky, David J., Shearn, Alisabeth H., Petersen, Dennis R.
Udgivet i Free Radic Biol Med (2017)

4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification

af Fritz, Kristofer S., Galligan, James J., Smathers, Rebecca L., Roede, James R., Shearn, Colin T., Reigan, Philip, Petersen, Dennis R.
Udgivet 2011

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

af Shearn, Colin T., Smathers, Rebecca L., Stewart, Benjamin J., Fritz, Kristofer S., Galligan, James J., Hail, Numsen, Petersen, Dennis R.
Udgivet 2011

Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

af Smathers, Rebecca L., Fritz, Kristofer S., Galligan, James J., Shearn, Colin T., Reigan, Philip, Marks, Michael J., Petersen, Dennis R.
Udgivet 2012

Nocturnal Hypoxia Induced Oxidative Stress Promotes Progression of Pediatric Non-Alcoholic Fatty Liver Disease

af Sundaram, Shikha S., Halbower, Ann, Pan, Zhaoxing, Robbins, Kristen, Capocelli, Kelley E., Klawitter, Jelena, Shearn, Colin T., Sokol, Ronald J.
Udgivet i J Hepatol (2016)

Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis

af Ronis, Martin, Mercer, Kelly, Engi, Bridgette, Pulliam, Casey, Zimniak, Piotr, Hennings, Leah, Shearn, Colin, Badger, Thomas, Petersen, Dennis
Udgivet i Am J Pathol (2017)

Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney

af Harris, Peter S., Roy, Samantha R., Coughlan, Christina, Orlicky, David J., Liang, Yongliang, Shearn, Colin T., Roede, James R., Fritz, Kristofer S.
Udgivet i Redox Biol (2015)

4-hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity

af Pan, Guodong, Deshpande, Mandar, Pang, Haiyan, Stemmer, Paul M., Carruthers, Nicholas J, Shearn, Colin T., Backos, Donald S., Palaniyandi, Suresh Selvaraj
Udgivet i J Cell Biochem (2020)

Profiling Impaired Hepatic Endoplasmic Reticulum Glycosylation as a Consequence of Ethanol Ingestion

af Galligan, James J., Fritz, Kristofer S., Tipney, Hannah, Smathers, Rebecca L., Roede, James R., Shearn, Colin T., Hunter, Lawrence E., Petersen, Dennis R.
Udgivet 2011

Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice

af Petersen, Dennis R., Saba, Laura M., Sayin, Volkan I., Papagiannakopoulos, Thales, Schmidt, Edward E., Merrill, Gary F., Orlicky, David J., Shearn, Colin T.
Udgivet i PLoS One (2018)

Susceptibility of L-FABP(−/−) mice to oxidative stress in early-stage alcoholic liver

af Smathers, Rebecca L., Galligan, James J., Shearn, Colin T., Fritz, Kristofer S., Mercer, Kelly, Ronis, Martin, Orlicky, David J., Davidson, Nicholas O., Petersen, Dennis R.
Udgivet 2013

Oxidative stress mediated aldehyde adduction of Grp78 in a mouse model of alcoholic liver disease: Functional independence of ATPase activity and chaperone function

af Galligan, James J., Fritz, Kristofer S., Backos, Donald S., Shearn, Colin T., Smathers, Rebecca L., Jiang, Hua, MacLean, Kenneth N., Reigan, Philip R., Petersen, Dennis R.
Udgivet i Free Radic Biol Med (2014)