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4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification

4-Hydroxynonenal (4-HNE) is an endogenous product of lipid peroxidation known to play a role in cellular signaling through protein modification and is a major precursor for protein carbonyl adducts found in alcoholic liver disease (ALD). In the present study, a greater than 2-fold increase in protei...

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Detalhes bibliográficos
Main Authors: Fritz, Kristofer S., Galligan, James J., Smathers, Rebecca L., Roede, James R., Shearn, Colin T., Reigan, Philip, Petersen, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3113719/
https://ncbi.nlm.nih.gov/pubmed/21449565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100355a
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