Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

The production of reactive aldehydes such as 4-hydroxynonenal (4-HNE) is proposed to be an important factor in the etiology of alcoholic liver disease. To understand the effects of 4-HNE on homeostatic signaling pathways in hepatocytes, cellular models consisting of the human hepatocellular carcinom...

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Bibliographic Details
Main Authors: Shearn, Colin T., Smathers, Rebecca L., Stewart, Benjamin J., Fritz, Kristofer S., Galligan, James J., Hail, Numsen, Petersen, Dennis R.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102545/
https://ncbi.nlm.nih.gov/pubmed/21415306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.110.069534
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