Oxidative stress mediated aldehyde adduction of Grp78 in a mouse model of alcoholic liver disease: Functional independence of ATPase activity and chaperone function

Pathogenesis in alcoholic liver disease (ALD) is complicated and multifactorial but clearly involves oxidative stress and inflammation. Currently, conflicting reports exist regarding the role of endoplasmic reticulum (ER) stress in the etiology of ALD. The glucose regulated protein 78 (GRP78) is the...

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Publicado no:Free Radic Biol Med
Main Authors: Galligan, James J., Fritz, Kristofer S., Backos, Donald S., Shearn, Colin T., Smathers, Rebecca L., Jiang, Hua, MacLean, Kenneth N., Reigan, Philip R., Petersen, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395467/
https://ncbi.nlm.nih.gov/pubmed/24924946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2014.06.002
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