Inhibition of hydrogen peroxide signaling by 4-Hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatoc...

Por Shearn, Colin T., Reigan, Philip, Petersen, Dennis R.
Publicado em 2012

Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease

Por Shearn, Colin T., Orlicky, David J., Petersen, Dennis R.
Publicado no Exp Mol Pathol (2017)

Lipid peroxidation derived reactive aldehydes in alcoholic liver disease

Por Ali, Hadi, Assiri, Mohammed A., Shearn, Colin T., Fritz, Kristofer S.
Publicado no Curr Opin Toxicol (2018)

Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis

Por Hail, Numsen, Chen, Ping, Kepa, Jadwiga J., Bushman, Lane R., Shearn, Colin
Publicado em 2010

Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model

Por Senchina, David S., Flinn, Gina N., McCann, Dustin A., Kohut, Marian L., Shearn, Colin T.
Publicado em 2009

Identification of 5′ AMP-activated Kinase as a Target of Reactive Aldehydes during Chronic Ingestion of High Concentrations of Ethanol

Por Shearn, Colin T., Backos, Donald S., Orlicky, David J., Smathers-McCullough, Rebecca L., Petersen, Dennis R.
Publicado em 2014

Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early stage ethanol-mediated steatosis

Por Shearn, Colin T., Smathers, Rebecca L., Jiang, Hua, Orlicky, David J., Maclean, Kenneth N., Petersen, Dennis R.
Publicado em 2013

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Signaling Regulates Mitochondrial Biogenesis and Respiration via Estrogen-related Receptor α (ERRα)

Por Li, Yang, He, Lina, Zeng, Ni, Sahu, Divya, Cadenas, Enrique, Shearn, Colin, Li, Wei, Stiles, Bangyan L.
Publicado em 2013

Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH

Por Shearn, Colin T., Saba, Laura M., Roede, James R., Orlicky, David J., Shearn, Alisabeth H., Petersen, Dennis R.
Publicado no Free Radic Biol Med (2017)

4-Hydroxynonenal Inhibits SIRT3 via Thiol-Specific Modification

Por Fritz, Kristofer S., Galligan, James J., Smathers, Rebecca L., Roede, James R., Shearn, Colin T., Reigan, Philip, Petersen, Dennis R.
Publicado em 2011

Phosphatase and Tensin Homolog Deleted on Chromosome 10 (PTEN) Inhibition by 4-Hydroxynonenal Leads to Increased Akt Activation in Hepatocytes

Por Shearn, Colin T., Smathers, Rebecca L., Stewart, Benjamin J., Fritz, Kristofer S., Galligan, James J., Hail, Numsen, Petersen, Dennis R.
Publicado em 2011

Characterization of 4-HNE Modified L-FABP Reveals Alterations in Structural and Functional Dynamics

Por Smathers, Rebecca L., Fritz, Kristofer S., Galligan, James J., Shearn, Colin T., Reigan, Philip, Marks, Michael J., Petersen, Dennis R.
Publicado em 2012

Nocturnal Hypoxia Induced Oxidative Stress Promotes Progression of Pediatric Non-Alcoholic Fatty Liver Disease

Por Sundaram, Shikha S., Halbower, Ann, Pan, Zhaoxing, Robbins, Kristen, Capocelli, Kelley E., Klawitter, Jelena, Shearn, Colin T., Sokol, Ronald J.
Publicado no J Hepatol (2016)

Global Deletion of Glutathione S-Transferase A4 Exacerbates Developmental Nonalcoholic Steatohepatitis

Por Ronis, Martin, Mercer, Kelly, Engi, Bridgette, Pulliam, Casey, Zimniak, Piotr, Hennings, Leah, Shearn, Colin, Badger, Thomas, Petersen, Dennis
Publicado no Am J Pathol (2017)

Chronic ethanol consumption induces mitochondrial protein acetylation and oxidative stress in the kidney

Por Harris, Peter S., Roy, Samantha R., Coughlan, Christina, Orlicky, David J., Liang, Yongliang, Shearn, Colin T., Roede, James R., Fritz, Kristofer S.
Publicado no Redox Biol (2015)

Profiling Impaired Hepatic Endoplasmic Reticulum Glycosylation as a Consequence of Ethanol Ingestion

Por Galligan, James J., Fritz, Kristofer S., Tipney, Hannah, Smathers, Rebecca L., Roede, James R., Shearn, Colin T., Hunter, Lawrence E., Petersen, Dennis R.
Publicado em 2011

Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice

Por Petersen, Dennis R., Saba, Laura M., Sayin, Volkan I., Papagiannakopoulos, Thales, Schmidt, Edward E., Merrill, Gary F., Orlicky, David J., Shearn, Colin T.
Publicado no PLoS One (2018)

Susceptibility of L-FABP(−/−) mice to oxidative stress in early-stage alcoholic liver

Por Smathers, Rebecca L., Galligan, James J., Shearn, Colin T., Fritz, Kristofer S., Mercer, Kelly, Ronis, Martin, Orlicky, David J., Davidson, Nicholas O., Petersen, Dennis R.
Publicado em 2013

Oxidative stress mediated aldehyde adduction of Grp78 in a mouse model of alcoholic liver disease: Functional independence of ATPase activity and chaperone function

Por Galligan, James J., Fritz, Kristofer S., Backos, Donald S., Shearn, Colin T., Smathers, Rebecca L., Jiang, Hua, MacLean, Kenneth N., Reigan, Philip R., Petersen, Dennis R.
Publicado no Free Radic Biol Med (2014)

Knock-out of the Gsta4 gene in male mice leads to an altered pattern of hepatic protein carbonylation and enhanced inflammation following chronic consumption of an ethanol diet

Por Shearn, Colin T., Pulliam, Casey F., Pedersen, Kim, Meredith, Kyle, Mercer, Kelly E., Saba, Laura M., Orlicky, David J., Ronis, Martin J., Petersen, Dennis R.
Publicado no Alcohol Clin Exp Res (2018)