Bacteria herald a new era of gene editing

Por Segal, David J
Publicado em 2013

Beyond the genome and into the clinic

Por Segal, David J
Publicado em 2012

The generation of zinc finger proteins by modular assembly

Por Bhakta, Mital, Segal, David J.
Publicado no Methods Mol Biol (2010)

Cold-Sensitive Mutants of Bacteriophage φX174. II. Comparison of Two Cold-Sensitive Mutants

Por Segal, David J., Dowell, Clifton E.
Publicado em 1974

The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders

Por Bailus, Barbara J, Segal, David J
Publicado em 2014

Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker

Por Shimizu, Yuka, Bhakta, Mital S., Segal, David J.
Publicado em 2009

Bind-n-Seq: high-throughput analysis of in vitro protein–DNA interactions using massively parallel sequencing

Por Zykovich, Artem, Korf, Ian, Segal, David J.
Publicado em 2009

How specific is CRISPR/Cas9 really?

Por O’Geen, Henriette, Yu, Abigail S., Segal, David J.
Publicado no Curr Opin Chem Biol (2015)

SEquence-Enabled Reassembly of β-Lactamase (SEER-LAC): a Sensitive Method for the Detection of Double-Stranded DNA

Por Ooi, Aik T., Stains, Cliff I., Ghosh, Indraneel, Segal, David J.
Publicado em 2006

Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences

Por Segal, David J., Dreier, Birgit, Beerli, Roger R., Barbas, Carlos F.
Publicado em 1999

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

Por Liu, Qiang, Segal, David J., Ghiara, Jayant B., Barbas, Carlos F.
Publicado em 1997

Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Por Beerli, Roger R., Segal, David J., Dreier, Birgit, Barbas, Carlos F.
Publicado em 1998

Conformational elasticity can facilitate TALE-DNA recognition

Por Lei, Hongxing, Sun, Jiya, Baldwin, Enoch P., Segal, David J., Duan, Yong
Publicado no Adv Protein Chem Struct Biol (2014)

A zinc finger protein array for the visual detection of specific DNA sequences for diagnostic applications

Por Kim, Moon-Soo, Stybayeva, Gulnaz, Lee, Ji Youn, Revzin, Alexander, Segal, David J.
Publicado em 2011

Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing

Por Meier, Jordan L., Yu, Abigail S., Korf, Ian, Segal, David J., Dervan, Peter B.
Publicado em 2012

Fusion Proteins Consisting of Human Immunodeficiency Virus Type 1 Integrase and the Designed Polydactyl Zinc Finger Protein E2C Direct Integration of Viral DNA into Specific Sites

Por Tan, Wenjie, Zhu, Kai, Segal, David J., Barbas III, Carlos F., Chow, Samson A.
Publicado em 2004

Crystallization and preliminary X-ray crystallographic analysis of Aart, a designed six-­finger zinc-finger peptide, bound to DNA

Por Crotty, Justin W., Etzkorn, Christopher, Barbas, Carlos F., Segal, David J., Horton, Nancy C.
Publicado em 2005

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

Por O'Geen, Henriette, Henry, Isabelle M., Bhakta, Mital S., Meckler, Joshua F., Segal, David J.
Publicado no Nucleic Acids Res (2015)

Unexpected binding behaviors of bacterial Argonautes in human cells cast doubts on their use as targetable gene regulators

Por O’Geen, Henriette, Ren, Chonghua, Coggins, Nicole B., Bates, Sofie L., Segal, David J.
Publicado no PLoS One (2018)

Inhibition of Human Immunodeficiency Virus Type 1 Replication with Artificial Transcription Factors Targeting the Highly Conserved Primer-Binding Site

Por Eberhardy, Scott R., Goncalves, Joao, Coelho, Sofia, Segal, David J., Berkhout, Ben, Barbas, Carlos F.
Publicado em 2006