Fusion Proteins Consisting of Human Immunodeficiency Virus Type 1 Integrase and the Designed Polydactyl Zinc Finger Protein E2C Direct Integration of Viral DNA into Specific Sites

In order to establish a productive infection, a retrovirus must integrate the cDNA of its RNA genome into the host cell chromosome. While this critical process makes retroviruses an attractive vector for gene delivery, the nonspecific nature of integration presents inherent hazards and variations in...

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Detalhes bibliográficos
Main Authors: Tan, Wenjie, Zhu, Kai, Segal, David J., Barbas III, Carlos F., Chow, Samson A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC321411/
https://ncbi.nlm.nih.gov/pubmed/14722285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.3.1301-1313.2004
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