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Guiding the Design of Synthetic DNA-Binding Molecules with Massively Parallel Sequencing
[Image: see text] Genomic applications of DNA-binding molecules require an unbiased knowledge of their high affinity sites. We report the high-throughput analysis of pyrrole-imidazole polyamide DNA-binding specificity in a 10(12)-member DNA sequence library using affinity purification coupled with m...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3483022/ https://ncbi.nlm.nih.gov/pubmed/23013524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja308888c |
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