A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence

Many RNAs cause disease; however, RNA is rarely exploited as a small-molecule drug target. Our programmatic focus is to define privileged RNA motif small-molecule interactions to enable the rational design of compounds that modulate RNA biology starting from only sequence. We completed a massive, li...

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Bibliographic Details
Published in:Chem
Main Authors: Childs-Disney, Jessica L., Tran, Tuan, Vummidi, Balayeshwanth R., Velagapudi, Sai Pradeep, Haniff, Hafeez S., Matsumoto, Yasumasa, Crynen, Gogce, Southern, Mark R., Biswas, Avik, Wang, Zi-Fu, Tellinghuisen, Timothy L., Disney, Matthew D.
Format: Artigo
Language:Inglês
Published: 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358276/
https://ncbi.nlm.nih.gov/pubmed/30719503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chempr.2018.08.003
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