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Small Molecule Targeted Recruitment of a Nuclease to RNA
The choreography between RNA synthesis and degradation is a key determinant in biology. Engineered systems such as CRISPR have been developed to rid a cell of RNAs. Here, we show that a small molecule can recruit a nuclease to a specific transcript, triggering its destruction. A small molecule that...
Shranjeno v:
| izdano v: | J Am Chem Soc |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6100793/ https://ncbi.nlm.nih.gov/pubmed/29792692 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b01233 |
| Oznake: |
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