Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

As the area of small molecules interacting with RNA advances, general routes to provide bioactive compounds are needed as ligands can bind RNA avidly to sites that will not affect function. Small-molecule targeted RNA degradation will thus provide a general route to affect RNA biology. A non–oligonu...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Costales, Matthew G., Aikawa, Haruo, Li, Yue, Childs-Disney, Jessica L., Abegg, Daniel, Hoch, Dominic G., Pradeep Velagapudi, Sai, Nakai, Yoshio, Khan, Tanya, Wang, Kye Won, Yildirim, Ilyas, Adibekian, Alexander, Wang, Eric T., Disney, Matthew D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007575/
https://ncbi.nlm.nih.gov/pubmed/31964809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914286117
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