Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

As the area of small molecules interacting with RNA advances, general routes to provide bioactive compounds are needed as ligands can bind RNA avidly to sites that will not affect function. Small-molecule targeted RNA degradation will thus provide a general route to affect RNA biology. A non–oligonu...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Costales, Matthew G., Aikawa, Haruo, Li, Yue, Childs-Disney, Jessica L., Abegg, Daniel, Hoch, Dominic G., Pradeep Velagapudi, Sai, Nakai, Yoshio, Khan, Tanya, Wang, Kye Won, Yildirim, Ilyas, Adibekian, Alexander, Wang, Eric T., Disney, Matthew D.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2020
נושאים:
Biological Sciences
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007575/
https://ncbi.nlm.nih.gov/pubmed/31964809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914286117
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