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Defining RNA motif–aminoglycoside interactions via two-dimensional combinatorial screening and structure–activity relationships through sequencing

RNA is an extremely important target for the development of chemical probes of function or small molecule therapeutics. Aminoglycosides are the most well studied class of small molecules to target RNA. However, the RNA motifs outside of the bacterial rRNA A-site that are likely to be bound by these...

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Detalhes bibliográficos
Main Authors: Velagapudi, Sai Pradeep, Disney, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789863/
https://ncbi.nlm.nih.gov/pubmed/23719281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.04.072
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