Two-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside–RNA hairpin loop interactions

Herein, we report the identification of RNA hairpin loops that bind derivatives of kanamycin A, tobramycin, neamine, and neomycin B via two-dimensional combinatorial screening, a method that screens chemical and RNA spaces simultaneously. An arrayed aminoglycoside library was probed for binding to a...

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Bibliographic Details
Main Authors: Paul, Dustin J., Seedhouse, Steven J., Disney, Matthew D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2009
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761267/
https://ncbi.nlm.nih.gov/pubmed/19726586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp594
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