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Two-Dimensional Combinatorial Screening (2DCS) of a Bacterial rRNA A-site-like Motif Library: Defining Privileged Asymmetric Internal Loops that Bind Aminoglycosides

RNAs have diverse structures that are important for biological function. These structures include bulges and internal loops that can form tertiary contacts or serve as ligand binding sites. The most commonly exploited RNA drug target for small molecule intervention is the bacterial ribosome, more sp...

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Bibliografske podrobnosti
Main Authors: Tran, Tuan, Disney, Matthew D.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846769/
https://ncbi.nlm.nih.gov/pubmed/20108982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901998m
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