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Two-Dimensional Combinatorial Screening (2DCS) of a Bacterial rRNA A-site-like Motif Library: Defining Privileged Asymmetric Internal Loops that Bind Aminoglycosides

RNAs have diverse structures that are important for biological function. These structures include bulges and internal loops that can form tertiary contacts or serve as ligand binding sites. The most commonly exploited RNA drug target for small molecule intervention is the bacterial ribosome, more sp...

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Autors principals: Tran, Tuan, Disney, Matthew D.
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2846769/
https://ncbi.nlm.nih.gov/pubmed/20108982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi901998m
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