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Restricted spacer tolerance of a zinc finger nuclease with a six amino acid linker
Zinc finger nucleases can be engineered to create highly efficient and precise changes to the genetic information within living cells. We report the investigation of an important parameter that defines the type of target site the nuclease can cleave. The active nuclease is a dimer, requiring that th...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2709702/ https://ncbi.nlm.nih.gov/pubmed/19289279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.02.109 |
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