Decomposing the Energetic Impact of Drug-Resistant Mutations: The Example of HIV-1 Protease - DRV Binding

von Cai, Yufeng, Schiffer, Celia
Veröffentlicht in Methods Mol Biol (2012)

Resilience to Resistance of HIV-1 Protease Inhibitors: Profile of Darunavir

von Lefebvre, Eric, Schiffer, Celia A.
Veröffentlicht 2008

Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV

von Cai, Yufeng, Schiffer, Celia A
Veröffentlicht 2010

REdiii: a pipeline for automated structure solution

von Bohn, Markus-Frederik, Schiffer, Celia A.
Veröffentlicht in Acta Crystallogr D Biol Crystallogr (2015)

APOBEC3s: DNA‐editing human cytidine deaminases

von Silvas, Tania V., Schiffer, Celia A.
Veröffentlicht in Protein Sci (2019)

Introduction: Drug Resistance

von Yilmaz, Nese Kurt, Schiffer, Celia A.
Veröffentlicht in Chem Rev (2021)

Structure-Based Prediction of Potential Binding and Nonbinding Peptides to HIV-1 Protease

von Kurt, Nese, Haliloglu, Turkan, Schiffer, Celia A.
Veröffentlicht 2003

New Approaches to HIV Protease Inhibitor Drug Design II: Testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

von Nalam, Madhavi N. L., Schiffer, Celia A.
Veröffentlicht 2008

Rationale for More Diverse Inhibitors in Competition with Substrates in HIV-1 Protease

von Ozer, Nevra, Schiffer, Celia A., Haliloglu, Turkan
Veröffentlicht 2010

Dynamics of Preferential Substrate Recognition in HIV-1 Protease: Redefining the Substrate Envelope

von Özen, Ayşegül, Haliloğlu, Türkan, Schiffer, Celia A.
Veröffentlicht 2011

HIV-1 Protease and Substrate Coevolution Validates the Substrate Envelope As the Substrate Recognition Pattern

von Özen, Ayşegül, Haliloğlu, Türkan, Schiffer, Celia A.
Veröffentlicht 2012

Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design

von Özen, Ayşegül, Sherman, Woody, Schiffer, Celia A.
Veröffentlicht 2013

Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease

von Soumana, Djadé I., Ali, Akbar, Schiffer, Celia A.
Veröffentlicht in ACS Chem Biol (2014)

Improving Viral Protease Inhibitors to Counter Drug Resistance

von Yilmaz, Nese Kurt, Swanstrom, Ronald, Schiffer, Celia A.
Veröffentlicht in Trends Microbiol (2016)

Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints

von Leidner, Florian, Kurt Yilmaz, Nese, Schiffer, Celia A.
Veröffentlicht in J Chem Inf Model (2019)

NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations

von Ishima, Rieko, Kurt-Yilmaz, Nese, Schiffer, Celia A.
Veröffentlicht in J Biomol NMR (2019)

Deciphering complex mechanisms of resistance and loss of potency through coupled molecular dynamics and machine learning

von Leidner, Florian, Yilmaz, Nese Kurt, Schiffer, Celia A.
Veröffentlicht in J Chem Theory Comput (2021)

Human Immunodeficiency Virus Type 1 Protease-Correlated Cleavage Site Mutations Enhance Inhibitor Resistance

von Kolli, Madhavi, Stawiski, Eric, Chappey, Colombe, Schiffer, Celia A.
Veröffentlicht 2009

Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

von Özer, Nevra, Özen, Ayşegül, Schiffer, Celia A, Haliloğlu, Türkan
Veröffentlicht in Evol Appl (2015)

Quantitative comparison of errors in (15)N transverse relaxation rates measured using various CPMG phasing schemes

von Myint, Wazo, Cai, Yufeng, Schiffer, Celia A., Ishima, Rieko
Veröffentlicht in J Biomol NMR (2012)