Therapeutic targeting of HES1 transcriptional programs in T-ALL

le Schnell, Stephanie A., Ambesi-Impiombato, Alberto, Sanchez-Martin, Marta, Belver, Laura, Xu, Luyao, Qin, Yue, Kageyama, Ryoichiro, Ferrando, Adolfo A.
Foilsithe in Blood (2015)

Translating cancer genomics into precision medicine with artificial intelligence: applications, challenges and future perspectives

le Xu, Jia, Yang, Pengwei, Xue, Shang, Sharma, Bhuvan, Sanchez-Martin, Marta, Wang, Fang, Beaty, Kirk A., Dehan, Elinor, Parikh, Baiju
Foilsithe in Hum Genet (2019)

Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL)

le Cantley, Alexandra M., Welsch, Matthew, Ambesi-Impiombato, Alberto, Sanchez-Martin, Marta, Kim, Mi-Yeon, Bauer, Andras, Ferrando, Adolfo, Stockwell, Brent R.
Foilsithe 2014

Structure and mechanisms of NT5C2 mutations driving thiopurine resistance in relapsed lymphoblastic leukemia

le Dieck, Chelsea L., Tzoneva, Gannie, Forouhar, Farhad, Carpenter, Zachary, Ambesi-Impiombato, Alberto, Sánchez-Martín, Marta, Kirschner-Schwabe, Renate, Lew, Scott, Seetharaman, Jayaraman, Tong, Liang, Ferrando, Adolfo A.
Foilsithe in Cancer Cell (2018)

Synergistic antileukemic therapies in NOTCH1-induced T-ALL

le Sanchez-Martin, Marta, Ambesi-Impiombato, Alberto, Qin, Yue, Herranz, Daniel, Bansal, Mukesh, Girardi, Tiziana, Paietta, Elisabeth, Tallman, Martin S., Rowe, Jacob M., De Keersmaecker, Kim, Califano, Andrea, Ferrando, Adolfo A.
Foilsithe in Proc Natl Acad Sci U S A (2017)

Comprehensive characterization of compartment specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma

le Arnes, Luis, Liu, Zhaoqi, Wang, Jiguang, Maurer, H. Carlo, Sagalovskiy, Irina, Sanchez-Martin, Marta, Bommakanti, Nikhil, Garofalo, Diana C., Balderes, Dina A., Sussel, Lori, Olive, Kenneth P., Rabadan, Raul
Foilsithe in Gut (2018)

Leukemia-specific delivery of mutant NOTCH1 targeted therapy

le Roti, Giovanni, Qi, Jun, Kitara, Samuel, Sanchez-Martin, Marta, Saur Conway, Amy, Varca, Anthony C., Su, Angela, Wu, Lei, Kung, Andrew L., Ferrando, Adolfo A., Bradner, James E., Stegmaier, Kimberly
Foilsithe in J Exp Med (2018)

CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance

le Pitt, Lauren A., Tikhonova, Anastasia N., Hu, Hai, Trimarchi, Thomas, King, Bryan, Gong, Yixiao, Sanchez-Martin, Marta, Tsirigos, Aris, Littman, Dan R., Ferrando, Adolfo, Morrison, Sean J., Fooksman, David R., Aifantis, Iannis, Schwab, Susan R.
Foilsithe in Cancer Cell (2015)

Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in acute lymphoblastic leukemia

le Herranz, Daniel, Ambesi-Impiombato, Alberto, Sudderth, Jessica, Sánchez-Martín, Marta, Belver, Laura, Tosello, Valeria, Xu, Luyao, Wendorff, Agnieszka A., Castillo, Mireia, Haydu, J. Erika, Márquez, Javier, Matés, José M., Kung, Andrew L., Rayport, Stephen, Cordon-Cardo, Carlos, DeBerardinis, Ralph J., Ferrando, Adolfo A.
Foilsithe in Nat Med (2015)

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia

le Furness, Caroline L, Mansur, Marcela B, Weston, Victoria J, Ermini, Luca, van Delft, Frederik W, Jenkinson, Sarah, Gale, Rosemary, Harrison, Christine J, Pombo-de-Oliveira, Maria S, Sanchez-Martin, Marta, Ferrando, Adolfo A, Kearns, Pamela, Titley, Ian, Ford, Anthony M, Potter, Nicola E, Greaves, Mel
Foilsithe in Leukemia (2018)

Multivalent small molecule pan-RAS inhibitors

le Welsch, Matthew E., Kaplan, Anna, Chambers, Jennifer M., Stokes, Michael E., Bos, Pieter H., Zask, Arie, Zhang, Yan, Sanchez-Martin, Marta, Badgley, Michael A., Huang, Christine S., Tran, Timothy H., Akkiraju, Hemanth, Brown, Lewis M., Nandakumar, Renu, Cremers, Serge, Yang, Wan S., Tong, Liang, Olive, Kenneth P., Ferrando, Adolfo, Stockwell, Brent R.
Foilsithe in Cell (2017)

Clonal evolution mechanisms in NT5C2 mutant relapsed acute lymphoblastic leukemia

le Tzoneva, Gannie, Dieck, Chelsea L., Oshima, Koichi, Ambesi-Impiombato, Alberto, Sánchez-Martín, Marta, Madubata, Chioma J., Khiabanian, Hossein, Yu, Jiangyan, Waanders, Esme, Iacobucci, Ilaria, Sulis, Maria Luisa, Kato, Motohiro, Koh, Katsuyoshi, Paganin, Maddalena, Basso, Giuseppe, Gastier-Foster, Julie M., Loh, Mignon L., Kirschner-Schwabe, Renate, Mullighan, Charles G., Rabadan, Raul, Ferrando, Adolfo A.
Foilsithe in Nature (2018)

Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

le Piovan, Erich, Yu, Jiyang, Tosello, Valeria, Herranz, Daniel, Ambesi-Impiombato, Alberto, Da Silva, Ana Carolina, Sanchez-Martin, Marta, Perez-Garcia, Arianne, Rigo, Isaura, Castillo, Mireia, Indraccolo, Stefano, Cross, Justin R, de Stanchina, Elisa, Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M, Tallman, Martin S, Basso, Giuseppe, Meijerink, Jules P, Cordon-Cardo, Carlos, Califano, Andrea, Ferrando, Adolfo A.
Foilsithe 2013

Tumor-specific HSP90 inhibition as a therapeutic approach in JAK-mutant acute lymphoblastic leukemias

le Kucine, Nicole, Marubayashi, Sachie, Bhagwat, Neha, Papalexi, Efthymia, Koppikar, Priya, Sanchez Martin, Marta, Dong, Lauren, Tallman, Marty S., Paietta, Elisabeth, Wang, Kai, He, Jie, Lipson, Doron, Stephens, Phil, Miller, Vince, Rowe, Jacob M., Teruya-Feldstein, Julie, Mullighan, Charles G., Ferrando, Adolfo A., Krivtsov, Andrei, Armstrong, Scott, Leung, Laura, Ochiana, Stefan O., Chiosis, Gabriela, Levine, Ross L., Kleppe, Maria
Foilsithe in Blood (2015)

Mutational landscape, clonal evolution patterns, and role of RAS mutations in relapsed acute lymphoblastic leukemia

le Oshima, Koichi, Khiabanian, Hossein, da Silva-Almeida, Ana C., Tzoneva, Gannie, Abate, Francesco, Ambesi-Impiombato, Alberto, Sanchez-Martin, Marta, Carpenter, Zachary, Penson, Alex, Perez-Garcia, Arianne, Eckert, Cornelia, Nicolas, Concepción, Balbin, Milagros, Sulis, Maria Luisa, Kato, Motohiro, Koh, Katsuyoshi, Paganin, Maddalena, Basso, Giuseppe, Gastier-Foster, Julie M., Devidas, Meenakshi, Loh, Mignon L., Kirschner-Schwabe, Renate, Palomero, Teresa, Rabadan, Raul, Ferrando, Adolfo A.
Foilsithe in Proc Natl Acad Sci U S A (2016)

Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias

le Wang, Kai, Sanchez-Martin, Marta, Wang, Xujun, Knapp, Kristina M., Koche, Richard, Vu, Ly, Nahas, Michelle K., He, Jie, Hadler, Michael, Stein, Eytan M, Tallman, Martin S., Donahue, Amy L, Frampton, Garrett M, Lipson, Doron, Roels, Steven, Stephens, Philip J., Sanford, Eric M, Brennan, Tim, Otto, Geoff A., Yelensky, Roman, Miller, Vincent A., Kharas, Michael G., Levine, Ross L., Ferrando, Adolfo, Armstrong, Scott A., Krivtsov, Andrei V.
Foilsithe in Leukemia (2016)