Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia

Glucocorticoid resistance is a major driver of therapeutic failure in T-cell acute lymphoblastic leukemia (T-ALL). Here we identify the AKT1 kinase as a major negative regulator of the NR3C1 glucocorticoid receptor protein activity driving glucocorticoid resistance in T-ALL. Mechanistically, AKT1 im...

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Main Authors: Piovan, Erich, Yu, Jiyang, Tosello, Valeria, Herranz, Daniel, Ambesi-Impiombato, Alberto, Da Silva, Ana Carolina, Sanchez-Martin, Marta, Perez-Garcia, Arianne, Rigo, Isaura, Castillo, Mireia, Indraccolo, Stefano, Cross, Justin R, de Stanchina, Elisa, Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M, Tallman, Martin S, Basso, Giuseppe, Meijerink, Jules P, Cordon-Cardo, Carlos, Califano, Andrea, Ferrando, Adolfo A.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878658/
https://ncbi.nlm.nih.gov/pubmed/24291004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2013.10.022
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