Genetic loss of SH2B3 in acute lymphoblastic leukemia

The SH2B adaptor protein 3 (SH2B3) gene encodes a negative regulator of cytokine signaling with a critical role in the homeostasis of hematopoietic stem cells and lymphoid progenitors. Here, we report the identification of germline homozygous SH2B3 mutations in 2 siblings affected with developmental...

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主要な著者: Perez-Garcia, Arianne, Ambesi-Impiombato, Alberto, Hadler, Michael, Rigo, Isaura, LeDuc, Charles A., Kelly, Kara, Jalas, Chaim, Paietta, Elisabeth, Racevskis, Janis, Rowe, Jacob M., Tallman, Martin S., Paganin, Maddalena, Basso, Giuseppe, Tong, Wei, Chung, Wendy K., Ferrando, Adolfo A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2013
主題:
Lymphoid Neoplasia
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790510/
https://ncbi.nlm.nih.gov/pubmed/23908464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-05-500850
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