Preclinical analysis of the gamma-secretase inhibitor PF-03084014 in combination with glucocorticoids in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemias and lymphomas (T-ALL) are aggressive hematologic cancers frequently associated with activating mutations in NOTCH1. Early studies identified NOTCH1 as an attractive therapeutic target for the treatment of T-ALL through the use of γ-secretase inhibitors (GSIs). He...

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Detalhes bibliográficos
Main Authors: Samon, Jeremy B., Castillo-Martin, Mireia, Hadler, Michael, Ambesi-Impiobato, Alberto, Paietta, Elisabeth, Racevskis, Janis, Wiernik, Peter H., Rowe, Jacob M., Jakubczak, John, Randolph, Sophia, Cordon-Cardo, Carlos, Ferrando, Adolfo A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3392513/
https://ncbi.nlm.nih.gov/pubmed/22504949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0938
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