Synergistic Effect of the γ-Secretase Inhibitor PF-03084014 and Docetaxel in Breast Cancer Models

Notch signaling mediates breast cancer cell survival and chemoresistance. In this report, we aimed to evaluate the antitumor efficacy of PF-03084014 in combination with docetaxel in triple-negative breast cancer models. The mechanism of action was investigated. PF-03084014 significantly enhanced the...

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Dettagli Bibliografici
Autori principali: Zhang, Cathy C., Yan, Zhengming, Zong, Qing, Fang, Douglas D., Painter, Cory, Zhang, Qin, Chen, Enhong, Lira, Maruja E., John-Baptiste, Annette, Christensen, James G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: AlphaMed Press 2013
Soggetti:
Cancer Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3659764/
https://ncbi.nlm.nih.gov/pubmed/23408105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2012-0096
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