Synergistic antitumor effect of a γ-secretase inhibitor PF-03084014 and sorafenib in hepatocellular carcinoma

As a multi-kinase inhibitor, sorafenib is beneficial in around 30% of hepatocellular carcinoma (HCC) patients; however, HCC patients develop acquired drug resistance quickly. Clinical benefits of sorafenib, in combination with transarterial chemoembolization (TACE), radiotherapy, and other chemodrug...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Yang, Xuran, Xia, Wei, Chen, Lin, Wu, Chuan Xing, Zhang, Cathy C., Olson, Peter, Wang, Xiao Qi
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201862/
https://ncbi.nlm.nih.gov/pubmed/30405889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26209
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