Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer

BACKGROUND: The NOTCH signaling pathway may be involved in the survival of stem cell-like tumor-initiating cells and contribute to tumor growth. In this phase Ib, open-label, multicenter study (NCT01876251), we evaluated PF-03084014, a selective gamma-secretase inhibitor in patients with advanced tr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Locatelli, Marzia A., Aftimos, Philippe, Dees, E. Claire, LoRusso, Patricia M., Pegram, Mark D., Awada, Ahmad, Huang, Bo, Cesari, Rossano, Jiang, Yuqiu, Shaik, M. Naveed, Kern, Kenneth A., Curigliano, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356802/
https://ncbi.nlm.nih.gov/pubmed/27906684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13727
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