Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

The TLX1 and TLX3 transcription factor oncogenes play an important role in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL)(1,2). Here we used reverse engineering of global transcriptional networks to decipher the oncogenic regulatory circuit controlled by TLX1 and TLX3. This Systems...

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Autori principali: Gatta, Giusy Della, Palomero, Teresa, Perez-Garcia, Arianne, Ambesi-Impiombato, Alberto, Bansal, Mukesh, Carpenter, Zachary W., De Keersmaecker, Kim, Sole, Xavier, Xu, Luyao, Paietta, Elisabeth, Racevskis, Janis, Wiernik, Peter H, Rowe, Jacob M, Meijerink, Jules P, Califano, Andrea, Ferrando, Adolfo A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3298036/
https://ncbi.nlm.nih.gov/pubmed/22366949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2610
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