The TLX1 oncogene drives aneuploidy in T-cell transformation

The TLX1 transcription factor oncogene plays an important role in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL). However, the specific mechanisms of T-cell transformation downstream of TLX1 remain to be elucidated. Here we show that forced expression of TLX1 in transgenic mice indu...

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Main Authors: De Keersmaecker, Kim, Real, Pedro Jose, Gatta, Giusy Della, Palomero, Teresa, Sulis, Maria Luisa, Tosello, Valeria, Van Vlierberghe, Pieter, Barnes, Kelly, Castillo, Mireia, Sole, Xavier, Hadler, Michael, Lenz, Jack, Aplan, Peter D., Kelliher, Michelle, Kee, Barbara L., Pandolfi, Pier Paolo, Kappes, Dietmar, Gounari, Fotini, Petrie, Howard, Van der Meulen, Joni, Speleman, Frank, Paietta, Elisabeth, Racevskis, Janis, Wiernik, Peter H., Rowe, Jacob M., Soulier, Jean, Avran, David, Cavé, Hélène, Dastugue, Nicole, Raimondi, Susana, Meijerink, Jules P.P., Cordon-Cardo, Carlos, Califano, Andrea, Ferrando, Adolfo A.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974790/
https://ncbi.nlm.nih.gov/pubmed/20972433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2246
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