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An activating intragenic deletion in NOTCH1 in human T-ALL
Oncogenic activating mutations in NOTCH1 occur in more than 50% of T-cell acute lymphoblastic leukemias (T-ALLs). In the present study, we describe a novel mechanism of NOTCH1 activation in T-ALL in which a deletion removing the 5′ portion of NOTCH1 abolishes the negative regulatory control of the e...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3369611/ https://ncbi.nlm.nih.gov/pubmed/22510873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-388504 |
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