An activating intragenic deletion in NOTCH1 in human T-ALL

Oncogenic activating mutations in NOTCH1 occur in more than 50% of T-cell acute lymphoblastic leukemias (T-ALLs). In the present study, we describe a novel mechanism of NOTCH1 activation in T-ALL in which a deletion removing the 5′ portion of NOTCH1 abolishes the negative regulatory control of the e...

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Main Authors: Haydu, J. Erika, De Keersmaecker, Kim, Duff, Mary Kaye, Paietta, Elisabeth, Racevskis, Janis, Wiernik, Peter H., Rowe, Jacob M., Ferrando, Adolfo
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369611/
https://ncbi.nlm.nih.gov/pubmed/22510873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-388504
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